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News
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Seminar Information
- 2024.3.28
- The seminar will be held on April 11, 2024. The instructor is Dr. Wladek Minor. Click here for more details.
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Seminar Information
- 2023.12.12
- The 39th seminar will be held on February 9, 2024. The instructor is Dr. Shigeki Kiyonaka. Click here for more details.
Publication list updated
- 2023.12.12
- The paper "A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities" is published in Proceedings of the National Academy of Sciences of the United States of America. See publication page. ※ This paper was featured in the News and views section of Nature ＜Nature News and views＞
Publication list updated
- 2023.12.12
- The paper "Specific protonation of acidic residues confers K+ selectivity to the gastric proton pump" is published in Journal of Biological Chemistry. See publication page.
Publication list updated
- 2023.9.26
- The paper "Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding" is published in Nature Communications. See publication page.
Publication list updated
- 2023.9.20
- The paper "Deep learning driven de novo drug design based on gastric proton pump structures" is published in Communications Biology. See publication page.
Publication list updated
- 2023.7.31
- The paper "The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel" is published in Nature Communications. See publication page.
Seminar Information
- 2023.7.26
- The 38th seminar will be held on September 8, 2023. The instructor is Dr. Tohru Terada. Click here for more details.
Publication list updated
- 2023.7.22
- The paper "An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding" is published in Biochimica et Biophysica Acta Molecular Cell Research. See publication page.
Publication list updated
- 2023.7.20
- The paper "Three structures of PSI-LHCI from Chlamydomonas reinhardtii suggest a resting state re-activated by ferredoxin" is published in Biochimica et Biophysica Acta Bioenergetics. See publication page.
Seminar Information
- 2023.6.5
- The 37th seminar will be held on July 10, 2023. The instructor is Dr. Motoyuki Hattori. Click here for more details.
Seminar Information
- 2023.6.5
- The 36th seminar will be held on June 16, 2023. The instructor is Dr. Yuichiro Aiba. Click here for more details.
Seminar Information
- 2023.3.31
- The 34th seminar will be held on April 10, 2023. The instructor is Dr. Poul Nissen. Click here for more details.
Publication list updated
- 2023.3.20
- The paper "Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit" is published in Journal of Molecular Biology. See publication page.
Article Information
- 2023.3.16
- An article titled "The Mechanism of the Strongest Ion Pump Revealed by SPring-8 and Cryo-Electron Microscopy: Understanding the Mechanism of Stomach Acid Formation and Its Application to Drug Discovery" appeared in Research Results and Topics in SPring-8 NEWS No. 111 (March 2023). Click HP for more details.
Joint Research
- 2023.2.22
- We have started a joint research with Intage Healthcare Inc. on gastric acid inhibitors using AI drug discovery.
Seminar Information
- 2023.1.24
- The 33th seminar will be held on January 27, 2023. The instructor is Dr. George Chikenji. Click here for more details.
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Seminar Information
- 2022.11.4
- The 32th seminar will be held on November 28, 2022. The instructor is Dr. Takayuki Uchihashi. Click here for more details.
Seminar Information
- 2022.10.7
- The 31th seminar will be held on October 28, 2022. The instructor is Valentin-Mihai Dospinescu (University of Warwick). Click here for more details.
Publication list updated
- 2022.9.12
- The paper "Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms" is published in Nature Communications. See publication page.
Seminar Information
- 2022.9.7
- The 30th seminar will be held on September 16, 2022. The instructor is Dr. Hidekazu Hiroaki. Click here for more details.
Publication list updated
- 2022.7.15
- The paper "Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM" is published in Communications Biology. See publication page.
Seminar Information
- 2022.6.24
- The 29th seminar will be held on July 15, 2022. The instructor is Dr. Akihiro Narita. Click here for more details.
Publication list updated
- 2022.5.24
- The paper "Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump" is published in Journal of Medicinal Chemistry. See publication page.
Publication list updated
- 2022.2.9
- The paper "Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N-terminus and phospholipids" is published in Science Signaling. See publication page.
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Publication list updated
- 2021.12.17
- The paper "Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2" is published in Journal of Biological Chemistry. See publication page.
Award received
- 2021.11.9
- Dr. Yoshinori Fujiyoshi (currently Distinguished Professor, Tokyo Medical and Dental University), former Director of Cellular and Structural Physiology Institute, was awarded the Order of the Sacred Treasure, Gold and Silver Star. All of us would like to extend our heartfelt congratulations.
Publication list updated
- 2021.9.29
- The paper "Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations" is published in Nature Communications. See publication page.
Workshop Information
- 2021.8.6
- Workshop on Cryo-Electron Microscopy and Single Particle Analysis (2021/10/05) will be held. As an activity of the Japan Agency for Medical Research and Development (AMED) " Basis for Supporting Innovating Drug Discovery and Life Science Research (BINDS)", this workshop aims to provide beginners with an overview of single particle analysis using cryo-electron microscopy. Click here for more details.
The workshop is free of charge, but please register in advance.
- ➡ ※The application has been closed.
Award Commemorative Lecture
- 2021.6.14
- Prof. Atsunori Oshima gave a lecture in commemoration of the 13th Kazato Prize at the 77th Annual Meeting of the Japanese Society of Microscopy.
New Assistant Professor
- 2021.6.1
- Dr. Kotaro Tanaka has joined as an assistant professor.
Seminar Information
- 2021.03.26
- The 28th seminar will be held on April 27, 2021. The instructor is Dr. Kotaro Tanaka. Click here for more details.
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Publication list updated
- 2020.10.26
- The 27th seminar will be held on November 30, 2020. The instructor is Dr. Masaki Kita (Professor, Nagoya University). Click here for more details.
Publication list updated
- 2020.09.30
- The paper "Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM" is published in Cell Reports. See publication page.
Publication list updated
- 2020.06.05
- The paper "Crystal structure of a human plasma membrane phospholipid flippase" is published in Journal of Biological Chemistry. See publication page.
Publication list updated
- 2020.04.27
- The paper "Structural insights into gap junction channels boosted by cryo-EM" published in Current Opinion in Structural Biology. See publication page.
The paper introduced in Nature
- 2020.03.12
- The paper "A native proxy voltage-dependent calcium channel with a novel selectivity filter sequence" published in February 2020 in eLife was introduced in <Nature＞.
Award received
- 2020.03.09
<- Professor Atsunori Oshima received the 13th (FY 2019) "Kazato Prize". See more about Kazato Prize here.
Publication list updated
- 2020.02.25
- Publication list updated. See publication page.
Publication list updated
- 2020.02.12
- Publication list updated. See publication page.
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Publication list updated
- 2019.08.23
- Publication list updated. See publication page.
Update publication list
- 2019.03.01
- Review on Current Opinion in Structural Biology has posted (Title: Potential of cryo-EM for high-resolution structural analysis of gap junction channels). See publication page.
Update publication list
- 2019.02.18
- Press Release on Nature Communications has posted (Title: Morphologic determinant of tight junctions revealed by claudin-3 structures). See publication page.
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Update organization page
- 2014.11.10
- Add Merck Ltd. Japan
to organization info.
Homepage Renewal
- 2014.05.21
- Update contents and design. In particular, the research content is refreshed.
Update organization page
- 2014.03.12
- Add Astellas Pharama Inc.
to organization info.
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Update organization page
- 2013.12.10
- Add MITSUI CHEMICALS AGRO,
ORIENTAL YEAST CO.,LTD. and
Oriental Bioservice, Inc.
to organization info.
Update organization page
- 2013.06.27
- Add Takara Bio Inc. to organization info.
Update organization page
- 2013.06.03
- Add SANWA KAGAKU CO., LTD. and JEOL Ltd. to organization info.
Homepage Renewal
- 2013.05.02
- Update contents and design. In particular, the research content is refreshed.
New director
- 2013.04.01
- Prof. Hidekazu Hiroaki is appointed as the director of CeSPI.
The greetings from here.
Information of Nagoya Symposium
- 2013.01.22
- On the Occasion of the Inauguration of the Cellular and Structural Physiology Institute and the NEDO Project at Nagoya University.
Details from here.
an article mentioning our center
- 2013.01.10
- Publised on Nature Japan
See details in Japanese from here.
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Director's message
- 2012.04.01
- Prof. Yoshinori Fujiyoshi is inducted as the first director of CeSPI. His message accessed from here.
Open Homepage
- 2012.04.01
- With the establishment of CeSPI.
